Archive for the ‘Vaccines’ Category

Signs of Autism in an Infant’s First Year

Sunday, October 23rd, 2016

neighborsAs a neonatal-perinatal specialist, I have been responsible for the health of tens of thousands of the smallest, sickest, and most vulnerable patients. Plus, in the past decade, I have focused on learning about, diagnosing, and treating children who are affected with the newest childhood developmental epidemic, Autism Spectrum Disorder.

It is fair to say, then, that my observations have a degree of validity not necessarily found by simply shopping around town, when parents seek answers about their child’s condition. Special needs pediatric medicine is my natural state. little-leoSo, while walking our Yorkie recently, as I was exchanging pleasantries with a neighbor, I couldn’t help but ‘examine’ the infant in the carriage. “Is this kid developing correctly?” I thought. “Are there red flags? What further questions would I want to know, short of becoming a nuisance, to help the family?”

Here is my list of key questions to best assess whether I should encourage a parent to further explore their infant’s development:

What is the age of mother and father?
Perhaps it isn’t the assisted pregnancy (in-vitro fertilization, etc.) that is the problem, since that has not been scientifically proven. But, an advanced maternal or paternal age have been shown to represent a significant association.
little-thought-cloudNo need to ask, however; I can ascertain that information by checking with my wife.

Has there been any medication use, but especially tylenol and psychoactive substances, even if they were prescribed by a doctor.
little-thought-cloudMaybe that’s too nosy.

Labor & Delivery:
Was it a full term pregnancy?
Contrary to some theories, I do not believe that pitocin (intravenous medicine given to enhance contractions) is a related issue. Rather, the fact that labor is prolonged may be due to hypotonia in the fetus, and he/she is not contributing in the tug of war. So, ‘Failure to Progress’, and late deliveries are a particular concern. Conversely, if the child was preterm, that is a significant risk factor, as well.

Did the child go home from the hospital with Mom?
This information could open up a host of possible associations, from the early use of antibiotics to birth defects.
“Why are you asking so many questions, Doc?”

“Well, I’m just interested. Did the child breast feed?”
Answers in the negative that are due to ‘poor suck’, breast milk ‘intolerance’, or GERD definitely increase the number of red flags related to those children who demonstrate future developmental concerns.

Does the child have to go to the doctor often?
Numerous visits to the pediatrician or specialists imply an underlying medical problem, including asthma, eczema, feeding and stooling problems, which are frequently associated in children with autism.

Did the baby have plagiocephaly (flat head), torticollis (wry neck), or a large head size? Does he make good eye contact and follow a moving human face? In the second half of the first year, does the baby crawl/walk OK? Is there vocalization?
little-thought-cloudSkip the interrogation, I can observe many of those signs for myself.

When the majority of answers are of concern, there may be enough warning signs to warrant further exploration. On one single day last week, I took care of 16 children who had criteria consistent with ASD. We don’t need more patients with autism. Something is just wrong.

Your neighbor should not be making developmental assessments, even if he is TheAutismDoctor. Pediatricians can, and must, do more to examine your infant’s development and help stem the tide. The only question should be, “What does your doctor think?”

For the clinician who may complain that this line of questioning causes unnecessary apprehension for Mom and Dad, my reply is that they are worried, anyway. Rather than help, a practitioner’s cavalier dismissal that, “I wouldn’t be concerned about that,” carries little substance in the face of this wide-ranging malady known as ASD.

I Watched Vaxxed

Monday, October 3rd, 2016

I am not against childhood vaccinations.

I have expressed that opinion in more than a few blogposts. Nonetheless, it appears that more information is needed, and controversies must be addressed, before the gods of modern medicine can simply dismiss the thousands of parents who feel that their child developed autism shortly after one of the childhood inoculations.


(L-R) Jenny, Jacqueline&Chris Laurita (housewives of NJ), Nico&Davida LaHood, Del Bigtree, Dawn&Ryan Neufeld, Jodi Gomes

This week, at the Autism Summit, Jenny McCarthy expressed that same opinion in her opening video, and throughout the panel discussion. Frankly, I would not have even written this story if there wasn’t a controversy when an Express-News reporter was prevented from attending the conference. He wrote, “The summit is being put on by Generation Rescue, a non-profit led by Jenny McCarthy, an anti-vaccine activist.”

One of the panelists was a San Antonio area District Attorney Nico LaHood. “In a promotional video filmed in his office, LaHood said “vaccines can and do cause autism,” and has made clear he doesn’t accept scientific evidence as proof to the contrary.” Another celebrity was Del Bigtree, the producer of Vaxxed.

So, I paid my four bucks, and watched the movie. Del Bigtree presents a compelling story surrounding the information supplied by CDC whistleblower, William Thompson, who claims that data that would have implicated vaccinations as a cause of autism was altered, so that the MMR would appear safe.

There is a fair amount of anecdotal and perhaps, overly dramatic presentations of individual case histories, which will turn off the ‘real’ scientists. Mr. Bigtree describes that as the conundrum as we, “…study the disconnect between science and parents.”

Dr. Doreen Granpeesheh, founder of CARD, appears as a credible expert. A nobel prize winner weighs in, adding validity to the story. After reviewing the data, a traditional pediatrician and family practitioner seem truly amazed – and changed their opinion about the safety studies. Cool, calm, and well-spoken, Wakefield looks to be anything but a raving zealot. His conclusion is that if the MMR were separated, that would be best solution and the issue of ‘herd immunity’ would not be breached.

I’m not against childhood vaccinations.
Hillary has declared, “The sky is blue and vaccinations work.” She doesn’t know, for sure, if they are safe for all, however. Why deliver an increasing number of antigens to an immature immune system? Why do we have a vaccine compensation fund? Why does the package insert say ‘seizures‘?

If such a movie only adds fuel to the fire, why not just refute the questions that are raised with a prospective, randomized, double blind study, considered to be the gold standard for proving efficacy and safety? Rather, people who even view the film are marginalized and considered kooky, conspiratorist, poorly informed, and ignorant.

The movie is considered to be the problem. Andrew Wakefield is the problem. Leo Kanner, a Freudian from the first half of the last century, assigned the diagnosis to the realm of psychiatry. Bruno Bettleheim, a media darling at the time, popularized the ‘refrigerator mom’ theory that persisted for another 30 years. We are still arguing if there even IS an epidemic. There is plenty of blame to go around regarding our confusion about this mysterious illness.

I’m old enough to have experienced neighbors, relatives and patients who have suffered serious consequences from childhood diseases, such as polio, measles, and congenital rubella. Furthermore, I am aware of the mountain of ‘scientific evidence’ that documents a lack of association to Autism Spectrum Disorder. In my own practice, the majority of parents do not feel that vaccines caused their child’s autism, and there are many children with ASD who never received any inoculation.

However, great concern is raised when there are stories, such as the mismanagement of vaccines in public clinics, and issues with government oversight connected to Big Pharma (documented in this movie).

This is one of the most polarizing issues that impedes real progress in our understanding of the epidemic of childhood autism. In the present circumstance, perhaps it was the fault of the conference organizers, not allowing a possibly negative story to emerge. This highlights the need for both sides to step back and listen to each other in order to uncover the truth.

Finally, I want to document that, I’m not against childhood vaccinations.

Medical Academy of Pediatric Special Needs – Fall 2016

Sunday, September 11th, 2016

This week, the Medical Academy of Pediatric Special Needs held its semiannual conference in downtown Atlanta, GA. This is ‘Ground 0’ for practitioners, researchers and professors from all over the world to meet, learn, explore and discuss a myriad of relevant topics.

Members who have been returning for 100’s of lecture hours generally choose the advanced courses. For some, the conference has become a group of ~50 experienced and knowledgeable practitioners who meet to discuss ‘workups’, basic science, relevant research and treatment protocols for those who are most affected with ASD.

Notes and Observations
Day 1 – Tough Cases
I really enjoyed our lectures by the plain-speaking Dr. John Green, of Portland, OR. Dr. Green not only reviewed those who improved because of his medical expertise, but those who got better in spite of him, those who haven’t gotten better, those who got better but he can’t figure out why, and the most frustrating – patients who improve only to suffer frequent relapses.

Dr. Sid Baker, a pioneer of the biomedical movement, described his early medical experiences in Africa that morphed into his lifelong dedication to treating patients with ASD. He expressed his disappointment that so many conventional colleagues disagree with our practice.

Dr. Baker elucidated how he initiates care with new patients. He discussed increasingly resistant cases, covering topics from severe speech apraxia to the approach to children with injurious behaviors.

The first day was filled with the most frustrating and difficult cases you can imagine. Eminent practitioners Drs. James Neuenshwander, Michael Elice, and Julie Buckley challenged our diagnostic and therapeutic knowledge, attempting to navigate the complicated courses of those who improved and those who didn’t.

Day 2
Dr. Daniel Amen‘s morning lecture was entitled “3D Brain SPECT Imaging”. The takeaway message was that SPECT scans – technology – could/should/will become a mainstay for a multitude of CNS disorders. His manner and stories of research, technical evaluation, and clinical practice, were positively spellbinding and inspirational.

Dr. Theoharides presented his research and extensive knowledge about the important role of allergy in ASD. Dr. Theo continues to publish a mountain of monumental works, not only on the topics of autism and the role of mast cells, but treatments, as well.

Toxins were the subject of the afternoon’s lectures. We learned about the identification of substances in the environment that are dangerous, how they are measured, how damage is done, and the means to control and treat. For the skeptical reader, there was a plethora of supporting scientific evidence of the relationships to autism (and many other modern conditions).

As has become customary, Dr. Dan Rossignol rounded up the day with a roundup of all of the latest scientific research. Rapidly.

Day 3 – Advanced Clinical Cases
Severe behaviors and speech apraxia. For patients who are most resistant to conventional and alternative treatments, essential oils, acupuncture, and even worms were explored as possible solutions.

Throughout the afternoon, cases got even tougher! Lyme, Persistent Lyme, Non-Lyme Lyme, PANDAS, PANS, parasites… an increasing number of reasons to have signs and symptoms that are called autism. Such information extends our knowledge and leads to better diagnoses for our patients, and possibilities for treatment.

Dr. Green discussed biomarkers. Though these ‘labs’ are not specific to ASD, per se, this will become a necessary next step to document level of involvement and response to treatments.

A brand new treatment, repetitive Transcranial Magnetic Stimulation was presented by Dr. Arun Mukherjee. The jury is still out on this expensive intervention.

One important reason that I return to this meeting, is simply that I feel at home among like-thinking practitioners. Members don’t agree on every subject, but we are respectful and actually enjoy our practices.

In traditional medicine, conferences are basically show-and-tell affairs, where researchers report their data, previously published in medical journals. When doctors think outside the box, practitioners with diverse skills, who are scattered over the globe, discover improved results by networking in this fashion.

Patients, parents, and families can feel confident that progress is being made (slowly), as serious, dedicated doctors continue to try to unravel this modern mystery.

Finally, I am proud to report that, at this meeting, I was awarded Fellowship status in the Medical Academy of Pediatric Special Needs.

Acetaminophen And Autism

Sunday, July 10th, 2016

A Tylenol® by any other name; including Xumadol, Paracetamol, Tirol, Calpol, Panadol, etc, etc.

Evidence supporting an another pharmaceutical connection to autism was recently presented in a study entitled, Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms, which appeared in The International Journal of Epidemiology.

Given our current state of ignorance, support, rejection, and often, polarizing opinions have already surfaced.

The Present Study
The authors concluded, “Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders…”

Recent Supporting Evidence
2014: Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders
Conclusion – “Maternal acetaminophen use during pregnancy is associated with a higher risk for HKDs and ADHD-like behaviors in children.”

2014: Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years
Conclusion – These findings strengthen the contention that acetaminophen exposure in pregnancy increases the risk of ADHD-like behaviors.

2013: Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort
Conclusion – “Children exposed to long-term use of paracetamol during pregnancy had substantially adverse developmental outcomes at 3 years of age.”

Opposing Opinions
2016: Use of acetaminophen (paracetamol) during pregnancy and the risk of autism spectrum disorder in the offspring.
Summary – “… the empirical data are very limited, but whatever empirical data exist do not support the suggestion that the use of acetaminophen during pregnancy increases the risk of autism in the offspring.”

Dr. James Cusack, research director of Autistica, “…insisted there was “not sufficient evidence” to back the suggestion. “The results presented are preliminary in their nature, and so should not concern families or pregnant women.”

The ‘experts’ say, “Don’t even worry about those studies”
claiming a relationship between Autism and Acetaminophen.
Where is the proof that it’s SAFE?

First available in US in the 1950s, Tylenol Elixir for children became even more popular 30 years later when aspirin was reported as a contributing factor to an often fatal Liver – CNS disorder (Reye’s Syndrome). Interestingly, the authors of a 2007 literature review wrote, “The suggestion of a defined cause-effect relationship between aspirin intake and Reye syndrome in children is not supported by sufficient facts.”

Throughout the globe, there are over 100 names for acetaminophen. Plus, it is an ingredient in hundreds of other over-the-counter remedies. It is widespread and readily available. The increased use of this chemical tracks with the explosion of autism into the 21st century.

The medication can cause liver problems and freely crosses the placenta. There are studies that link pretreatment with Tylenol to address fever associated with childhood inoculations, and an increased risk of ASD. Furthermore, the mechanism of action includes the creation of oxidative stress, which is thought to play a significant role in autism.

What about occasional use? The present research concluded, “These associations seem to be dependent on the frequency of exposure.” However, until further investigations are performed, there could be specific times in pregnancy that are more sensitive than others, regardless of the dose.

A single, relatively uncomplicated question – whether there is an association between Tylenol and ASD – needs to be answered. This is but one example of why numerous other substances in our poisoned environment are so difficult to pin down. And, forget about combinations of substances. Why is the establishment so quick to point out the weakness of the present research, and declare that, “Everything is fine?”

Until more information is collected, conservative advice is warranted. Acetaminophen usage in pregnancy should be placed high on the ‘This Deserves Further Study’ list of important autism associations.

From the New York Times – 9/24/26
The Trouble with Tylenol and Pregnancy

Diatomaceous Earth as Autism Treatment?

Sunday, May 15th, 2016

Parents frequently inquire about, and/or try, various home remedies. In a continuing effort to keep this site complete, by covering as many autism treatment modalities as possible, this discussion will be about diatomaceous earth.

What is DE?
“Isn’t that the stuff that you put into swimming pool filters?” Yes, but the supplement form is “Food Grade, 100% natural, with no side effects.” Except diarrhea, and a host of unstudied changes in fluids and minerals throughout the body.

OSHA and The National Institute for Occupational Safety have set limits for human exposure. Composition varies greatly. According to a prominent proponent, “Out of 600 deposits in the U.S., only 4 rate in purity by FDA standards to be labeled as ‘Food Grade'”.

The product was discovered over 150 years ago, and consists of the fossilized remains of millions of microscopic sea critters. According to Wiki, “…It is used as a filtration aid, mild abrasive in products including metal polishes and toothpaste, mechanical insecticide, absorbent for liquids, matting agent for coatings, reinforcing filler in plastics and rubber, anti-block in plastic films, porous support for chemical catalysts, cat litter, activator in blood clotting studies, a stabilizing component of dynamite, and a thermal insulator.”

Use in Health
There are claims of more than 1,500 benefits; including, lowering blood pressure and cholesterol, healing sore joints, healthier hair, skin, teeth, gums, and nails, better bowel movements and it is supposedly safe for pregnant women (no source).

Use in Autism
Agents that remove toxic metals – chelators – have been used as autism treatments since the turn of this century. When detoxification became a popular treatment, DE was introduced. As the issue of symptom-causing parasites (including fungi, viri, and bad bacteria) waxes, this cathartic product has received new mention. Anecdotal stories abound. Sensory issues, ADHD, behavioral disorders, and even speech, have apparently been changed for the better after administration, for some.

A Google search for ‘diatomaceous earth’ and ‘autism’ returns >27,000 responses. A Google Scholar search for this supplement returns ZERO valid, scientific hits.

The problem originates with the fact that conventional – and even biomedical treatments – are not relieving enough people who display the signs and symptoms of ASD. Home remedies are attempted to fill the void. However, autism consists of many conditions, so comparing disparate treatments is nearly impossible, outside of a scientific study. Importantly, parents are not aware of the parameters to follow; including laboratory testing of electrolytes, minerals, and the health of key organs, such as the liver and kidney.

It has been the experience of many practitioners that such gut-cleansing treatments – from worms, to CD, to Miralax™ –  only help selected patients, and then, for a brief period of time. Plus, conditions may worsen. Expect a paucity of testimonials about those negative reactions. Plus only a few warnings appear in the web.

Practitioners should listen carefully to parents who discover supplements that improve their children with ASD. A variety of valuable information has been provided, moving successful protocols forward. Likewise, it is our job to consider the scientific implications, as well. Unregulated substances lead to metabolic consequences that have yet to be elucidated.

As with other alternative alternatives, more reliable data is needed before experimenting on our children.

Mothers Day Wishes

Sunday, May 8th, 2016

helpMomThis is dedicated to all of the incredible Mothers who deal with ASD and the associated symptoms every day. You are not alone.

We’re not seeking miracle cures
Just small miracles.

I wish that I had more time for…

My affected child, the other kid(s), my husband, myself.

Something is just not right with my child, I wish we could figure it out.

If he would only get ready in the morning, Such a battle.

If she would just say “yes” once in a while.

If they will just stop fighting all of the time.

If he could only remember what he just read.

If he would only have some friends.

The family doesn’t’ seem to understand our problems.

We haven’t taken a vacation since…

If she wasn’t so disruptive in school.

If we could just figure out how to get him to focus.

He keeps saying the same thing over and over.

Those ‘stims’ are driving us crazy.

If we could all only get a good night’s sleep.

He has had diarrhea ever since I can remember.

He eats so little, I’m afraid he’s not getting enough.

She seems to be sick all of the time.

The rashes don’t ever seem to go away.

When do you think she will say “mama”?

There used to be some words, but now there’s not even eye contact.

She doesn’t ever play with us.

I wish she would stop biting her arms.

I wish he would stop hitting his mom.

When do you think he will be able to crawl?

She couldn’t stand until she was 2.

I don’t know what he wants.

If the doctors would only figure out what is wrong. If they would only listen.

How is my child going to make it in: preK, K, first grade, middle school, high school, life?

We’re not looking for miracle cures, just small miracles.

Thanks for allowing us to help
Dr. Udell and the staff at
The Child Development Center of America

Medical Academy of Pediatric Special Needs 2016 Spring Conference

Sunday, May 1st, 2016

Practitioners, such as myself, find that it is necessary to attend the bi-annual Medical Academy of Pediatric Special Needs conference for two important reasons. First, to listen to experts from all over the world present their knowledge and latest research. Second, to network with, and learn from, other like-minded practitioners.

What I Liked Best
This year, I chose the ADHD path. The workups that were presented tended to be somewhat complex, and perhaps unattainable for many patients. The bottom line was to get a medical evaluation. The differential diagnosis ranges from thyroid to PANDAS. Mostly all agreed that stimulant and psychotropic meds should not be the first line in treatment. One professor spent some time questioning the diagnosis, itself, and how the modern world has contributed to the epidemic.

What I Liked Least
Traveling all the way to Costa Mesa, CA. Course work is 8 hours per day, so no time for Disneyland, etc.

This Year’s Major Focus
Mitochondrial function continued to play a big role in the presentations. The advanced courses involved lots of methylation, detoxification, and energy production diagrams. The newest twist has been the addition of genetic testing to better determine the cause(s) of inadequately functioning biologic pathways. Single nucleotide polymorphisms (SNPs) and ‘epigenetics’ were the buzzwords – how individual genes interact with the environment and within the individual leading to dysfunction and downstream signs and symptoms.

Topics That Were Discussed in Passing
Microarray genetic testing, covering multiple genes, did not play a big part in this year’s talks. Discussions about childhood immunizations underlie a great deal of the members’ conversations; specifically the lack of solid scientific evidence for safety in high risk populations. Attendees are not against vaccinations, by the way. Lyme disease was discussed in general, and as that inflammatory process relates to other infectious-metabolic conditions.

Subjects Not Formally Presented
GcMAF and nagalase levels. Some patients have indicated that a useful, safe supply may become available, so that will help determine future use. As well, chlorine dioxide, hyperbaric oxygen treatment, helminths, medical marijuana, and stem cell therapy were not offered by this year’s presenters.

It is disappointing to return from such conferences without that ‘magic bullet’. Just standing around, listening to Sid Baker speak about how he got interested in autism, or asking him how the ‘ion cleaning’ footpath worked, is worth the price of admission, however. This science started with Dr. Baker, and he continues to be an inquisitive, gentle force for hope, 40 years later.

In the absence of a sufficient population of scientists who are willing and available to address this modern epidemic of childhood developmental problems, this meeting stands as a bastion against the current state of ignorance.

Vaccination Redux

Sunday, April 17th, 2016

TheAutismDoctor has been asked to weigh in on the recent media attention regarding the film Vaxxed, which was scheduled, but not shown, at this year’s Tribeca Film Festival.

Robert De Niro, who helped organize the exposition, announced that he has an 18 year-old son with autism, and felt that the point of view presented in the documentary was important enough to explore. However, he decided to pull the film because the controversy is so heated that it deterred the public’s enjoyment of the rest of the event.

Do Vaccinations cause Autism?
The topic has been covered in this venue over 35 times, so I’m fairly certain that another protestation will confer little additional sanity.

Regardless of the volume and frequency with which Jenny McCarthy, Robert De Niro or Dr. Udell voice the opinion that we are not against childhood inoculations, ‘anti-vaccination’ is usually the way that the information is characterized. Opinions are either, “All or none, for or against, pro-science or anti-vaccination, educated or ignorant, healthy or dangerous.” Such points of view offer no middle ground and so this dispute won’t go away any time soon.

I posed the following question to the ‘pro-vax’ father of a 6-month old, “You are asked to enter your baby into a formal study in which there are two groups.”

Group A – Present Schedule

Start at birth (Hepatitis B in hospital)
Fever OK (give Tylenol)
Mild illness OK
9 or more components at once OK
Negative previous reaction OK
‘Make up shots’ (for missed doses) OK
Other medical conditions OK
Development not on track OK

Group B – Other factors considered

Wait to begin until infant is clearly healthy
No shots if child is sick
Fewer components at each time
No pretreatment with Tylenol
Medical evaluation if previous problems
Appropriate testing if medically unstable (e.g. frequent infections, premature, GERD, eczema, asthma, abnormal stooling…)

Dad’s answer? “The safe one!” Really? Is that the one that the ‘scientists’ and government say is all right? And by the way, even if a physician might answer the hypothetical by responding, “Group A is perfectly fine,” their partner would probably protest, “Are you crazy? Not my kid!”

When that scenario is too cumbersome to recite, I pose another question. “Which is a more reasonable statement? ALL vaccinations are good for ALL children ALL of the time,” or “SOME inoculations might not be good for SOME toddlers in SOME situations?”

If the answer is the latter, it begs the question, “Which ones, when, under what conditions?”

Childhood vaccinations have been a true victory for modern medicine. They have prevented a variety of devastating diseases suffered by so many for millennia.

This movie, subtitled, From Cover-up to Catastrophe certainly stokes the controversy, as does its outspoken lightning rod, Andrew Wakefield.

No matter how frequently, dogmatic or pedantic the ‘Vaxxers’ pontificate, this polarization will continue until we understand more abut the present autism epidemic. Once that diagnosis is accurately understood and described, ‘real’ science demands independent, prospective, randomized, controlled, double-blind crossover studies of each and every component of the modern protocol to prove safety and efficacy.

Echolalia in Autism

Sunday, April 10th, 2016

Among the variety of perplexing signs exhibited by patients with autism is speech repetition. Increased understanding of the genesis and purpose of reiteration of words or phrases assists in our knowledge of ASD, and in developing useful therapeutic interventions.

As applied to autism, echolalia is the immediate or delayed repetition of vocalizations. In our electronic world, sounds don’t only come from other people. Imitation is common as toddlers start to speak, but persistence beyond the age of three continues in 3/4 of children ‘on the Spectrum’.

Representative literature:
Research described echolalia as a contrary language-related rationale emanating from the study and from the literature.

It is argued that researchers who propose intervention programs of echo-abatement may be overlooking the important communicative and cognitive functions echolalia may serve for the autistic child.

The diversity of delayed echolalic behavior is discussed in reference to its conventionality, the presence or absence of communicative intent, and its status as symbolic communicative activity.

Utilizing Behavioral therapy:
… Stimulation and echolalia decreased during treatment, and appropriate behaviors increased.
… Spontaneous social interactions and the spontaneous use of language occurred about eight months into treatment for some of the children.
… IQs and social quotients reflected improvement during treatment.
… There were no exceptions to the improvement, however, some of the children improved more than others.
… Follow-up measures recorded 1 to 4 years after treatment showed that large differences between groups of children depended upon the post-treatment environment (those groups whose parents were trained to carry out behavior therapy continued to improve, while children who were institutionalized regressed).

The Autism Doctor’s observations about the condition:
lightbulb littleIt is not uncommon to observe parents who repeatedly prompt, possibly providing a template for that speech pattern. “Tell the doctor your name. Tell the doctor your name.”

lightbulb littleWhy does the behavior occasionally seem to arise out of nowhere? By observing children who are finally healthy enough to produce vocalizations, they are practicing – singing songs over and over, and stuff that just pops into their heads.

lightbulb littleThe core symptoms of autism include restricted interests and repetitive behaviors. Speech recurrence sometimes appears to represent those issues. Echolalia is not merely, “Not getting it.”

lightbulb littleWith the frequent use of digital media and the ability to observe and listen to scenes over and over, imitation follows naturally.

lightbulb littleSpeech delay, another common sign, results in paucity of language. Children who wish to communicate, but who only possess 30% of ‘normal’ vocabulary, may be repeating each phrase 3 times, just to make up the difference.

Even today, echolalia is sometimes noted as non-functional at best, or possibly annoying at worst. After all, what parent hasn’t been driven crazy but the oft-repeated phrase, “When we gonna get there?”

As a clue to the deficiency of productive communication in ASD, this sign is important for our understanding of the bigger picture.

Strategies aimed at reduction ought to include expanding useful communication, rather than extinguishing, that vocal activity.

Top Autism Stories of 2015

Tuesday, December 29th, 2015

An end-of-the-year search for publications using the term AUTISM returned ~ 58,000 entries:
√ Treatment = 32,000 results
√ Diagnosis = 19,000 items
√ Cause = 19,000 records
√ Prevention = 10,000 entries

Here are the stories that represent this year’s salient research and experience (according to TheAutsimDoctor, at least):

Reduced GABAergic Action in the Autistic Brain
Evidence of this neurotransmitter showing reduced activity in the autistic brain. The supplement form is not able to cross into the brain However, it is sometimes helpful as a calming agent, though the opposite effect also occurs.

Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers
“Further underscoring the prenatal origins of ASD, researchers… describe for the first time how abnormal gene activity… may underlie abnormal early brain growth in the disorder.”

Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children
This is a BIG DEAL, to be discussed in a future posting.

Transcranial Direct Current Stimulation Treatment in an Adolescent with Autism and Drug-Resistant Catatonia
A possible new (and really expensive) treatment for ASD?

Oxytocin ‘Love Hormone’ Nasal Spray Shows Promise in Kids With Autism
Previously reviewed here.

Someone at the American Academy of Pediatrics gets it.

Association Between Obstetric Mode of Delivery and Autism Spectrum Disorder
This research bears out my experience as a neonatologist; the type of birth, per se, does not appear to lead to ASD.

Draft Recommendation Statement
Autism Spectrum Disorder in Young Children: Screening
A formal recommendation not supporting a toddler screen for ASD! Discussed in depth here.

A New Interactive Screening Test for Autism Spectrum Disorders in Toddlers.
But, if a screen is used, here is a better mousetrap.

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A
How gene function/malfunction can lead to downstream CNS processing errors.

A Mechanistic Link between Olfaction and Autism Spectrum Disorder
Patients don’t have Sensory Processing Disorder AND autism. Until it’s called something else, the condition is ASD.

Long-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder
“This is the first study to examine the role of early… behavioral intervention initiated at less than 30 months of age in altering the longer-term developmental course of autism.”

Autism risk associated with parental age and with increasing difference in age between the parents
If this is more than a mere association, it provides evidence of the environment interacting on genes (epigenetics).

Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample
Nature > Nurture study.

Long-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder
Yes, Virginia, early detection and intervention DOES matter.

Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices.
A comment from the New England Journal of Medicine: “A Blood Test for Predicting Autism?
It can’t be used for diagnosis just yet, but its findings may form the foundation for a more predictive test.”

Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism
Another study proving that ALL vaccinations, given at ANY age, in ANY combination, are good for ALL children, ALL of the time. Lies, damn lies, and statistics.

Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort
Higher maternal exposure to toxins during pregnancy, particularly in the last few months, were associated with greater odds of a child having ASD.

The autism-associated chromatin modifier ​CHD8 regulates other autism risk genes during human neurodevelopment
Discussion of epigenetics – how the environment works on genes.

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
It’s not news to the ASD community… “Autism Genes Found to Be Associated with Brighter Minds

Shorter spontaneous fixation durations in infants with later emerging autism
Even the youngest children may demonstrate high risk signs. 

A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder
An important step in diagnosing and treating any condition, is to have reproducible lab tests to assess risk, degree of involvement, and efficacy of intervention(s).

Explaining the Increase in the Prevalence of Autism Spectrum Disorders
The Proportion Attributable to Changes in Reporting Practices
It’s merely reassignment of diagnosis. NOT.

Is the U.S. Prepared for a Growing Population of Adults With Autism?
Since we aren’t prepared for the present growth of children on the spectrum, how could it be possible that future resources will be available?

Promising Forecast for Autism Spectrum Disorders
This editorial, which appeared in a respected medical journal, crystalizes the differences between what pediatricians think they know about ASD, and what parents actually experience. In practice, progress seems anemic and glacial. Autism is rocket science, mired in a political, emotional, and financial morass.

The top autism stories of 2015 are not enough. We need to recognize the epidemic, publish more information that assures vaccine safety for susceptible populations, address causes, safe and effective treatments, possible preventions, and how to address the aging of the autism population. Affected families just need more of everything.

As always, readers are invited to share their thoughts about this research,
and any other scientific papers 
that should be included.

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